Anxiolytic and antipyretic properties of the root aqueous extract of Bombax costatum Pellegr. et Vuillet. (Bombacaceae) in mice: Implication of behavioural and neurochemical approaches

Ethnopharmacological relevance: Bombax costatum Pellegr. et Vuillet. (Bombacaceaea) is a plant used in traditional medicine Cameroon to treat memory impairment, anxiety, insomnia and agitation. Aim of the study: The aqueous extract evaluated for its anxiolytic like effect mice using experimental models. Materials methods: administered orally mice. They were tested one hour later stress-induced hyperthermia, hole board, open field or elevated plus maze tests, respectively. Finally, brain Gamma aminobutyric acid [GABA] content GABA-T quantified extract-treated at end test. Results: showed activity. In hyperthermia test, significantly antagonised increase temperature. There significant reduction from 1.13 ± 0.06? negative control group treated with distilled water 0.26 0.02? 100 mg/kg extract. addition, antipyretic activity by reducing body increased number entries into, percentage time arms. It also reduced closed Conclusion: obtained results suggested that extracts possess anxiolytic-like activities This could be helpful treatment anxiety fever Cameroon.